Glycocalyx and extracellular matrix in cardiovascular disease and cancer
Ye Zeng, PhD
Institute of Biomedical Engineering
West China school of Preclinical and Forensic Medicine, Sichuan University
Chengdu 610041, China
Extracellular matrix which contains a diversity of secreted proteoglycans with attached GAGs and adhesive glycoproteins provides the available environment for cell-cell or cell-substrate communication and supports the cell adhesive that are critical to the structural integrity. On the cell surface, a well-investigated multifunctional layer of glycans that is often referred to as the glycoclayx has received broad interest over the past decade. As we known, in endothelial cells, glycocalyx interacts with cytokines and sensors the hemodynamic forces and subsequently transducing into cell to trigger the intracellular signaling cascade, playing important roles in cell survival, migration, invasion, and mechanotransduction of shear stress, contributing to inflammation and various diseases, such as cardiovascular diseases and cancer. In fact, glycocalyx also present on other cell types including cancer cells. For detection and visualization of the changes in extracellular matrix and glycocalyx, new imaging methodologies such as orthogonal polarization spectral imaging technology, sidestream dark field imaging technology, and immunofluorescence staining and confocal laser scanning microscopy have been developed. Researches on the pathophysiology and therapeutic implications for cardiovascular disease and cancer, and on the underlying mechanism might present a novel treatment strategy for those disease.
The special issue aims to highlight recent progression in extracellular matrix and glycocalyx, with an emphasis on the detection, visualization, clinical implications and the response and underlying mechanism in the pathogenesis of cardiovascular disease and cancer. The journal “Journal of Biomedicine” is open to receiving submissions with regard to original research articles, perspectives, and review articles in this area. The topics here should include, but not be limited to:
- Detection and visualization techniques
- Structure and Function
- Response, regulation and underlying mechanism
- Advances in pathophysiology and therapeutic implications for cardiovascular disease and cancer
Manuscripts for the special issue can be submitted online at http://www.jbiomed.com/ms/submit?subgroup=extracellular (mark "Extracellular Special Issue" in the "Suggested reviewers" field to identify the paper).
Detailed formatting instructions, in particular, the formatting of references, can be found in http://www.jbiomed.com/ms/author.
All inquiries should be sent to the guest editor(s) at the above email address.