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J Biomed 2016; 1:1-4. doi:10.7150/jbm.16497 This volume Cite

Research Paper

Dietary Intake of Vitamin D Is Related to Blood Levels of Advanced Glycation End Products during a Weight Loss Program in Obese Women

Shin Sukino¹, Kazuhiko Kotani^1,2,3, Shinsuke Nirengi¹, Alejandro Gugliucci³, Russell Caccavello³, Kokoro Tsuzaki¹, Yaeko Kawaguchi¹, Kaoru Takahashi⁴, Kahori Egawa⁵, Hiroshi Shibata⁵, Makiko Yoshimura⁶, Yoshinori Kitagawa⁷, Naoki Sakane^1✉

1. Division of Preventive Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;
2. Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-City, Tochigi, Japan;
3. Glycation, Oxidation and Disease Laboratory, Touro University-California, CA, USA;
4. Hyogo Health Service Association;
5. Institute for Health Care Science, Health Care Science Center, Suntory Wellness Limited, Kyoto, Japan;
6. HE Center, R&D Support Division, Suntory Business Expert Limited, Kyoto, Japan;
7. Safety Science Institute, Quality Assurance Division, Suntory Business Expert Limited, Kyoto, Japan.

✉ Corresponding author: Naoki Sakane, MD, PhD. Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto 612-8555, Japan. Tel: +81-75-641-9161 Fax: +81-75-645-2781 E-mail: nsakanehosp.go.jp. More

Abstract

BACKGROUND/OBJECTIVES: Advanced glycation end products (AGEs) contribute to the pathophysiology of lifestyle-related diseases. To identify nutrients associated with AGEs, this study explored the factors by investigating the relationship between nutrients changes and changes of blood AGEs during a weight loss program in obese women.

SUBJECTS/METHODS: Twenty-five obese women (age: 50 ± 8 years, body mass index: 28.7 ± 3.4 kg/m²) underwent a weight loss program with energy-restricted meal replacement for 2 months. Three-day weighted dietary records and blood tests including blood AGEs were performed at the baseline and after the 2-month intervention. Their correlation was examined during the intervention period.

RESULTS: The changes in AGEs were significantly and negatively correlated with those of intake levels of vitamin D (r = -0.54; P < 0.05).

CONCLUSION: Vitamin D might be a useful nutrient to reduce AGEs in obese women.

Keywords: AGEs, weight loss, vitamin D.

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