J Biomed 2019; 4:7-13. doi:10.7150/jbm.29161

Review

Gene Therapy for Hepatocellular Carcinoma: An Update

Christoforos Kosmidis1, Georgios Koimtzis1, George Pantos2, Stefanos Atmatzidis1, Efstathios Pavlidis1, Maria Kosmidou3, Christoforos Efthimiadis4, George Anthimidis4, Nikolaos Varsamis1, Eleni Georgakoudi1, Alexandros Tsakalidis1, Ioannis Koskinas1, Aristokles Paraschou1, Konstantina Tsopouridou1, Nikos Tteralli1, Triantafyllia Koletsa5, Katerina Zarampouka5, Isaac Kesisoglou1, Konstantinos Sapalidis1, Paul Zarogoulidis6✉

1. 3rd Department of Surgery, “AHEPA” University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece
2. Department of Obstetrics and Gynecologic Surgery, “G. Papageorgiou” Hospital, Aristotle University of Thessaloniki (AUTh), Thessaloniki, Greece
3. 1st Internal Medicine Division, University Hospital of Ioannina, University of Ioaninna, Medical School
4. Surgery Department, “Interbalkan” European Medical Center, Thessaloniki, Greece
5. Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
6. Pulmonary - Oncology Department, “Theageneio” Cancer Hospital, Thessaloniki, Greece

Abstract

Current statistics indicate that hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related death. Major predisposing conditions are hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. To date treatment approach includes liver transplantation, surgical resection and or ablation, however; recurrence, metastasis, and mortality still remains high. Therefore, alternative treatments such as gene therapy is increasingly being considered as a feasible proposal. In this mini review we will focus on novel data of the past 10 years on the subject of gene therapy and hepatocellular carcinoma.

Keywords: vectors, hepatocellular carcinoma, gene therapy

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How to cite this article:
Kosmidis C, Koimtzis G, Pantos G, Atmatzidis S, Pavlidis E, Kosmidou M, Efthimiadis C, Anthimidis G, Varsamis N, Georgakoudi E, Tsakalidis A, Koskinas I, Paraschou A, Tsopouridou K, Tteralli N, Koletsa T, Zarampouka K, Kesisoglou I, Sapalidis K, Zarogoulidis P. Gene Therapy for Hepatocellular Carcinoma: An Update. J Biomed 2019; 4:7-13. doi:10.7150/jbm.29161. Available from http://www.jbiomed.com/v04p0007.htm